Substantia nigra echogenicity: A structural correlate of functional impairment of the dopaminergic striatal projection in Parkinson's disease
Identifieur interne : 000954 ( Main/Exploration ); précédent : 000953; suivant : 000955Substantia nigra echogenicity: A structural correlate of functional impairment of the dopaminergic striatal projection in Parkinson's disease
Auteurs : David Weise [Allemagne] ; Reinhard Lorenz [Allemagne] ; Mira Schliesser [Allemagne] ; Andreas Schirbel [Allemagne] ; Karlheinz Reiners [Allemagne] ; Joseph Classen [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-08-15.
English descriptors
Abstract
Transcranial sonography (TCS) reveals abnormal spatial extension of substantia nigra (SN) echogenicity in a high proportion of patients with Parkinson's disease (PD). It has been proposed that this abnormality represents a structural trait that is mechanistically distinct from degeneration of dopaminergic nigrostriatal projection neurons. We sought to clarify the relationship between sonographic abnormalities of SN and dysfunction of striatal dopaminergic neurotransmission. We studied 50 patients with PD. The spatial extension of the echogenic SN area was compared with the activity of presynaptic striatal dopamine reuptake transporters, assessed in the same patients by I‐123‐2‐beta‐carbomethoxy‐3‐beta‐(4‐iodophenyl)‐tropane (β‐CIT) single‐photon emission computed tomography (SPECT). Extension of echogenic SN area correlated (inversely) with striatal activity of presynaptic dopamine reuptake transporter in PD patients (R = −0.417; P = 0.003) and with the equivalent levodopa dose (R = 0.380; P = 0.006; linear regression analysis). Findings support the hypothesis that in PD abnormal extension of echogenic SN area provides a direct structural marker of degeneration of SN neurons. Therefore, in PD, TCS and β‐CIT assess pathophysiologically related phenomena. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22665
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Substantia nigra echogenicity: A structural correlate of functional impairment of the dopaminergic striatal projection in Parkinson's disease</title><author><name sortKey="Weise, David" sort="Weise, David" uniqKey="Weise D" first="David" last="Weise">David Weise</name></author><author><name sortKey="Lorenz, Reinhard" sort="Lorenz, Reinhard" uniqKey="Lorenz R" first="Reinhard" last="Lorenz">Reinhard Lorenz</name></author><author><name sortKey="Schliesser, Mira" sort="Schliesser, Mira" uniqKey="Schliesser M" first="Mira" last="Schliesser">Mira Schliesser</name></author><author><name sortKey="Schirbel, Andreas" sort="Schirbel, Andreas" uniqKey="Schirbel A" first="Andreas" last="Schirbel">Andreas Schirbel</name></author><author><name sortKey="Reiners, Karlheinz" sort="Reiners, Karlheinz" uniqKey="Reiners K" first="Karlheinz" last="Reiners">Karlheinz Reiners</name></author><author><name sortKey="Classen, Joseph" sort="Classen, Joseph" uniqKey="Classen J" first="Joseph" last="Classen">Joseph Classen</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:34DF64A0E524BFB85FB6BCF4AA502B0A77D02B7C</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mds.22665</idno><idno type="url">https://api.istex.fr/document/34DF64A0E524BFB85FB6BCF4AA502B0A77D02B7C/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001885</idno><idno type="wicri:Area/Main/Curation">001638</idno><idno type="wicri:Area/Main/Exploration">000954</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Substantia nigra echogenicity: A structural correlate of functional impairment of the dopaminergic striatal projection in Parkinson's disease</title><author><name sortKey="Weise, David" sort="Weise, David" uniqKey="Weise D" first="David" last="Weise">David Weise</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Lorenz, Reinhard" sort="Lorenz, Reinhard" uniqKey="Lorenz R" first="Reinhard" last="Lorenz">Reinhard Lorenz</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, University of Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Schliesser, Mira" sort="Schliesser, Mira" uniqKey="Schliesser M" first="Mira" last="Schliesser">Mira Schliesser</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Schirbel, Andreas" sort="Schirbel, Andreas" uniqKey="Schirbel A" first="Andreas" last="Schirbel">Andreas Schirbel</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, University of Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Reiners, Karlheinz" sort="Reiners, Karlheinz" uniqKey="Reiners K" first="Karlheinz" last="Reiners">Karlheinz Reiners</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Classen, Joseph" sort="Classen, Joseph" uniqKey="Classen J" first="Joseph" last="Classen">Joseph Classen</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Leipzig, Leipzig</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Leipzig</region><settlement type="city">Leipzig</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-08-15">2009-08-15</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1669">1669</biblScope><biblScope unit="page" to="1675">1675</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">34DF64A0E524BFB85FB6BCF4AA502B0A77D02B7C</idno><idno type="DOI">10.1002/mds.22665</idno><idno type="ArticleID">MDS22665</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>neurodegeneration</term><term>transcranial sonography</term><term>β‐CIT SPECT</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Transcranial sonography (TCS) reveals abnormal spatial extension of substantia nigra (SN) echogenicity in a high proportion of patients with Parkinson's disease (PD). It has been proposed that this abnormality represents a structural trait that is mechanistically distinct from degeneration of dopaminergic nigrostriatal projection neurons. We sought to clarify the relationship between sonographic abnormalities of SN and dysfunction of striatal dopaminergic neurotransmission. We studied 50 patients with PD. The spatial extension of the echogenic SN area was compared with the activity of presynaptic striatal dopamine reuptake transporters, assessed in the same patients by I‐123‐2‐beta‐carbomethoxy‐3‐beta‐(4‐iodophenyl)‐tropane (β‐CIT) single‐photon emission computed tomography (SPECT). Extension of echogenic SN area correlated (inversely) with striatal activity of presynaptic dopamine reuptake transporter in PD patients (R = −0.417; P = 0.003) and with the equivalent levodopa dose (R = 0.380; P = 0.006; linear regression analysis). Findings support the hypothesis that in PD abnormal extension of echogenic SN area provides a direct structural marker of degeneration of SN neurons. Therefore, in PD, TCS and β‐CIT assess pathophysiologically related phenomena. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Leipzig</li><li>Saxe (Land)</li></region><settlement><li>Leipzig</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Weise, David" sort="Weise, David" uniqKey="Weise D" first="David" last="Weise">David Weise</name></noRegion><name sortKey="Classen, Joseph" sort="Classen, Joseph" uniqKey="Classen J" first="Joseph" last="Classen">Joseph Classen</name><name sortKey="Classen, Joseph" sort="Classen, Joseph" uniqKey="Classen J" first="Joseph" last="Classen">Joseph Classen</name><name sortKey="Lorenz, Reinhard" sort="Lorenz, Reinhard" uniqKey="Lorenz R" first="Reinhard" last="Lorenz">Reinhard Lorenz</name><name sortKey="Reiners, Karlheinz" sort="Reiners, Karlheinz" uniqKey="Reiners K" first="Karlheinz" last="Reiners">Karlheinz Reiners</name><name sortKey="Schirbel, Andreas" sort="Schirbel, Andreas" uniqKey="Schirbel A" first="Andreas" last="Schirbel">Andreas Schirbel</name><name sortKey="Schliesser, Mira" sort="Schliesser, Mira" uniqKey="Schliesser M" first="Mira" last="Schliesser">Mira Schliesser</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000954 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000954 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:34DF64A0E524BFB85FB6BCF4AA502B0A77D02B7C
|texte= Substantia nigra echogenicity: A structural correlate of functional impairment of the dopaminergic striatal projection in Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |